Polyunsaturated fatty acids and peripheral artery disease-Reference-Cited by-同舟云学术

Polyunsaturated fatty acids and peripheral artery disease

Published:2012-02 Issue:1 Volume:17 Page:51-63
ISSN:1358-863X
Container-title:Vascular Medicine
language:en
Short-container-title:Vasc Med

Author:

Grenon S Marlene¹²,Hughes-Fulford Millie²³⁴,Rapp Joseph¹²,Conte Michael S¹

Affiliation:

1. Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA, USA

2. San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA

3. Department of Medicine, University of California, San Francisco, San Francisco, CA, USA

4. Department of Urology, University of California, San Francisco, San Francisco, CA, USA

Abstract

There is substantial evidence that polyunsaturated fatty acids (PUFAs) such as n-3 and n-6 fatty acids (FAs) play an important role in prevention of atherosclerosis. In vitro and in vivo studies focusing on the interactions between monocytes and endothelial cells have explored the molecular effects of FAs on these interactions. Epidemiological surveys, followed by large, randomized, control trials have demonstrated a reduction in major cardiovascular events with supplementation of n-3 FAs in secondary prevention settings. The evidence of beneficial effects specific to patients with peripheral artery disease (PAD) remains elusive, and is the focus of this review.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1358863X11429175

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