Postprandial effects on arterial stiffness parameters in healthy young adults

Author:

Murray Tyler12,Yang Eric Y2,Brunner Gerd23,Kumar Anirudh24,Lakkis Nasser25,Misra Arunima25,Virani Salim S236,Hartley Craig J2,Morrisett Joel D2,Ballantyne Christie M23,Nambi Vijay236

Affiliation:

1. University of California San Francisco, San Francisco, CA, USA

2. Baylor College of Medicine, Houston, TX, USA

3. The Methodist Hospital-Michael E Debakey Heart and Vascular Institute, Houston, TX, USA

4. Duke University Medical Center, Durham, NC, USA

5. Harris County Hospital District – Ben Taub General Hospital, Houston, TX, USA

6. Michael E Debakey Veterans Affairs Hospital, Houston, TX, USA

Abstract

Postprandial lipemia has been associated with acute endothelial dysfunction. Endothelial dysfunction, in turn, is associated with increased arterial stiffness. However, the relationship between postprandial lipemia and acute changes in arterial stiffness has not been extensively investigated. Therefore, we conducted a pilot study on the effects of postprandial lipemia on arterial stiffness in 19 healthy young adults before and after consumption of a high-fat mixed meal. Arterial stiffness was assessed locally with echo-tracking carotid arterial strain (CAS) and globally with carotid–femoral pulse wave velocity (PWV). As assessed by these two benchmark parameters, arterial stiffness did not differ significantly postprandially. However, the arterial distension period (ADP) was significantly lower 2 hours after mixed meal ingestion. In addition, slopes of carotid artery area (CAA) curves were significantly steeper postprandially. Therefore, we concluded that ADP may be a more sensitive marker of arterial stiffness in healthy young adults when compared to PWV and CAS.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

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