New Thermo-responsive Hydrogels Based on Poly (N-isopropylacrylamide)/ Hyaluronic Acid Semi-interpenetrated Polymer Networks: Swelling Properties and Drug Release Studies-Reference-Cited by-同舟云学术

New Thermo-responsive Hydrogels Based on Poly (N-isopropylacrylamide)/ Hyaluronic Acid Semi-interpenetrated Polymer Networks: Swelling Properties and Drug Release Studies

Published:2010-01-12 Issue:2 Volume:25 Page:169-184
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Santos João R.¹,Alves Natália M.¹,Mano João F.²

Affiliation:

1. 3B's Research Group - Biomaterials, Biodegradables and Biomimetics AvePark, Zona Industrial da Gandra, S. Cláudio do Barco 4806-909 Caldas das Taipas - Guimarães, Portugal, IBB - Institute for Biotechnology and Bioengineering PT Government Associated Laboratory, Guimarães, Portugal

2. 3B's Research Group - Biomaterials, Biodegradables and Biomimetics AvePark, Zona Industrial da Gandra, S. Cláudio do Barco 4806-909 Caldas das Taipas - Guimarães, Portugal, IBB - Institute for Biotechnology and Bioengineering PT Government Associated Laboratory, Guimarães, Portugal,

Abstract

New pH and temperature sensitive semi-interpenetrated polymer networks (semi-IPNs) were developed by combining cross-linked PNIPAAm with hyaluronic acid (HA). At pH 7.4, the PNIPAAm/HA semi-IPN hydrogels had significantly greater and faster swelling at 25°C and a more complete deswelling at 37°C than PNIPAAm hydrogels. The temperature-dependent reversibility behavior was analyzed for biomaterial applications. Gentamicin was incorporated as a model drug, and the release profile from the hydrogels was followed under physiological conditions. The presence of HA, even in small quantities, allowed a more complete release of the gentamicin from the hydrogel. The PNIPAAm/HA semi-IPN hydrogels respond to both changes in temperature and pH making it suitable as a delivery system for therapeutics.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0883911509357863

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