Extracellular Matrix Components as Modulators of Adult Stem Cell Differentiation in an Adipose System-Reference-Cited by-同舟云学术

Extracellular Matrix Components as Modulators of Adult Stem Cell Differentiation in an Adipose System

Published:2008-01 Issue:1 Volume:23 Page:20-37
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Chaubey Aditya¹,Burg Karen J.L.²

Affiliation:

1. Department of Bioengineering, 501 Rhodes Engineering Research Center Clemson University, Clemson, SC 29634

2. Department of Bioengineering, 501 Rhodes Engineering Research Center Clemson University, Clemson, SC 29634,

Abstract

The viability of a cell-based device may be controlled post-implantation by managing the level of cellular differentiation. Cellular adhesion to extracellular matrix (ECM) proteins is fundamentally linked to tissue development, maintenance of tissue organization, and many pathological conditions. Cellular interaction with ECM regulates the proliferation and differentiation of cells. This study investigates the efficacy of ECM components (laminin and collagen) in modulating the differentiation of adult mouse bone marrow stem cells (D1) to adipocytes. This study should assist in the development of clinically viable soft-tissue implants.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0883911507085534

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