Antituberculosis Macromolecular Prodrugs: Part 1: Isoniazid Conjugates with Poly(Ethylene Glycol) Derivatives-Reference-Cited by-同舟云学术

Antituberculosis Macromolecular Prodrugs: Part 1: Isoniazid Conjugates with Poly(Ethylene Glycol) Derivatives

Published:1998-04 Issue:2 Volume:13 Page:146-157
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Cruz M. L.¹,Gil M. H.²

Affiliation:

1. Department of Pharmacy, Faculty of Medical Sciences, PUCCAMI? 13059-740, Campinas, SP, Brazil

2. Department of Chemical Engineering, FCTUC, University of Coimbra, 3000 Coimbra, Portugal

Abstract

The synthesis, elemental and spectrometric analysis of isoniazid conjugates with polyethylene glycol) (PEG) were obtained. In the first part of the work, acyl isoniazid, hydroxymethyl isoniazid, and modified poly(ethylene glycol) were synthesized. These compounds were characterized by FTIR, by elemental analysis, and by NMR. To obtain antituberculosis macromolecular prodrugs with sustained delivery, the modified PEG were used as carriers by linking, via end group, either isoniazid or its hydroxymethyl derivative.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391159801300206

Reference24 articles.

1. Multidrug-resistant tuberculosis and its control

2. Tuberculosis: Commentary on a Reemergent Killer

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