Bioactive Polymers XXXVI. Controlled Release of Cephalosporine C from Cellulosic Derivatives-Reference-Cited by-同舟云学术

Bioactive Polymers XXXVI. Controlled Release of Cephalosporine C from Cellulosic Derivatives

Published:1986-07 Issue:3 Volume:1 Page:285-300
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Dumitriu Severian¹,Popa Marcel¹

Affiliation:

1. Polytechnic Institute of Jassy Department of Organic and Macromolecular Chemistry 23 August 11, R-6600 Jassy, Romania

Abstract

Cephalosporine C was coupled onto cellulosic derivatives of N-(4-carboxy phenyl)carbamoylmethyl cellulose and crosslinked carboxymethyl cellulose to achieve controlled drug release. Starting from a mathematical model, the in fluence of certain parameters of the reaction (drug/support, activator/support molecular ratios, and reaction times) on the amount of Cephalosporine C chem ically bound to the cellulose products was determined. Evaluation of the cou pled products show extended activity by the release of Cephalosporine C by hydrolysis.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391158600100301

Reference29 articles.

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4. Robinson, J.R. "Controlled Release Pharmaceutical Systems," Chemical Marketing and Economics Reprints, F. W. Long , W. P. O'Neill, and R. D. Stewart, eds. American Chemical Society, San Francisco, p. 212 (1976).

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