Synthesis and Characterization of Non-Fouling Polymer Surfaces: I. Radiation Grafting of Hydroxyethyl Methacrylate and Polyethylene Glycol Methacrylate onto Silastic Film-Reference-Cited by-同舟云学术

Synthesis and Characterization of Non-Fouling Polymer Surfaces: I. Radiation Grafting of Hydroxyethyl Methacrylate and Polyethylene Glycol Methacrylate onto Silastic Film

Published:1986-07 Issue:3 Volume:1 Page:316-334
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Sun Y.H.¹,Gombotz W.R.¹,Hoffman A.S.¹

Affiliation:

1. Center for Bioengineering FL-20 University of Washington Seattle, WA 98195

Abstract

Polyethylene glycol (PEG) surfaces have been shown to be resistant to fouling by adsorbed proteins and cells. We have studied radiation induced graft copoly merization of hydroxyethyl methacrylate (HEMA) monomer and different molecular weight polyethylene glycol methacrylate (PEGMA) and methoxy PEGMA (MPEGMA) macromers onto Silastic film. The extent of grafting and chemical composition of the graft were found to be dependent on the HEMA/PEGMA ratio and the molecular weight of PEGMA. The influence of PEGMA molecular weight on grafting is explained in terms of both steric hin drance of PEG chains and the effect of radiation on the pendant polyether chains. Furthermore, the reactivity ratios in conventional copolymerizations initiated by y-ray or chemical initiators have been evaluated and compared with grafting reactivity ratios. The formation of interpenetrating chains was verified through microscopic observation of the cross section of the grafted film.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391158600100304

Reference17 articles.

1. Lin, S.C., Beahan, P., and Hull, D., Transactions of 8th Annual Meeting of Society for Biomaterials, Anaheim, p. 86 ( 1982).

2. Gregonis, D.E., Buerger, D.E., Van Wagenen, R.A., Hunter, S.K., and Andrade, J.D., Transactions of the Second World Congress on Biomaterials, Wash. D. C., p. 266 (1984).

3. Nagaoka, S. Mori, Y., Takiuchi, H., Yokota, K., Tanzawa, H., and Nishiumi, S., in Polymers as Biomaterials, Plenum Press, New York, p. 361 (1985).

Cited by 38 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. High-affinity one-step aptamer selection using a non-fouling porous hydrogel;Nature Biotechnology;2023-10-05

2. Electroresponsive Hydrogels for Therapeutic Applications in the Brain;Macromolecular Bioscience;2021-12

3. Phase behavior of methacrylic acid, poly(ethylene glycol) methyl ether, and poly(ethylene glycol) methacrylate in aqueous solutions;Polymer;2017-07

4. Functionalization with Interpenetrating Smart Polymer Networks by Gamma Irradiation for Loading and Delivery of Drugs;Responsive Materials and Methods;2013-10-21

5. Implantable enzyme amperometric biosensors;Biosensors and Bioelectronics;2012-05