Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells-Reference-Cited by-同舟云学术

Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells

Published:2009-01 Issue:1 Volume:24 Page:83-99
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Huade Li ¹,Qiang Zheng ¹,Yuxiang Xiao ¹,Jie Feng ²,Zhongli Shi ²,Zhijun Pan ³

Affiliation:

1. Department of Orthopaedics, The Second Affiliated Hospital Medical College, Zhejiang University, Hangzhou 310009, China

2. Institute of Orthopaedic Research, Hangzhou 310009, China

3. Institute of Orthopaedic Research, Hangzhou 310009, China,

Abstract

Biodegradable polymer/bioceramic composite poly(lactide- coglycolide)/hydroxyapatite(PLGA/HA) was studied for bone tissue engineering. The PLGA/HA composite was evaluated as a scaffold with the ability for mesenchymal stem cells (MSC) to participate in cartilage repair. The PLGA/HA composite and the PLGA/HA composite cultured with MSC were transplanted into cartilage defects created in rats. The PLGA/HA-MSC and PLGA/HA had better tissue morphology, structure integrity, matrix staining, and much thicker newly formed cartilage than the control group. The histological score for PLGA/ HA-MSC better than that for PLGA/HA; it appears that the MSC plays an important role in tissue repair. Based on these results, using PLGA/HA as the tissue scaffold and the addition of MSC significantly enhances cartilage repair.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0883911508100655

Reference42 articles.

1. Cartilage repair: Generations of autologous chondrocyte transplantation

2. Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin–chondroitin–hyaluronan tri-copolymer scaffold: A porcine model assessed at 18, 24, and 36 weeks

3. ROLE OF ABRASION ARTHROPLASTY AND DEBRIDEMENT IN THE MANAGEMENT OF OSTEOARTHRITIS OF THE KNEE

4. Arthroscopic abrasion arthroplasty historical and pathologic perspective: Present status

5. Current Concepts in the Treatment of Articular Cartilage Defects

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