Affiliation:
1. "Petru Poni" Institute of Macromolecular Chemistry, 6600 Iassy, Romania
Abstract
Dextran conjugates with nalidixic acid and oxacillin, were prepared in two ways: (a) by the reaction of the drugs with chloroacetylated crosslinked dextran microparticles and (b) by the reaction of the drugs with crosslinked polysaccharide microparticles in the presence of a coupling agent. The in vitro behavior of these conjugates was studied and the mechanism of drug release was determined.
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering