Hybrid Nanoapatite by Polysaccharide Nanogel-templated Mineralization-Reference-Cited by-同舟云学术

Hybrid Nanoapatite by Polysaccharide Nanogel-templated Mineralization

Published:2009-03 Issue:2 Volume:24 Page:151-168
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Yamane Setsuko¹,Sugawara Ayae²,Watanabe Akihiko¹,Akiyoshi Kazunari³

Affiliation:

1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

2. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan, epartment of Chemical System Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

3. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan,

Abstract

Self-assembled nanogels of cholesterol-bearing mannan (CHM) containing phosphodiester bonds in its structure were used as templates for calcium phosphate mineralization to prepare novel organic—inorganic hybrid nanocarriers for drug-delivery systems. These hybrid materials were synthesized from a solution of calcium phosphate in the presence of CHM nanogels. The size and crystallinity of the nanomaterials were controlled by changing the calcium ion concentration. Spherical amorphous calcium phosphate (ACP) nanoparticles of ~20 nm in size and needle-shaped hydroxyapatite (HAp) crystals ~80 nm in length were formed from solutions of [Ca2+] = 0.8 and 2.0 mM, respectively. These hybrid nanomaterials showed excellent colloidal stability in solution, which was supported by the polymer chains of CHM on the outer surface of the hybrid nanomaterials. It was also found that an amorphous-to-crystalline transformation occurred during the formation of CHM nanogel-HAp hybrid nanomaterials.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0883911508101554

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