Cerebrum Repair with PHPMA Hydrogel Immobilized with Neurite-Promoting Peptides in Traumatic Brain Injury of Adult Rat Model-Reference-Cited by-同舟云学术

Cerebrum Repair with PHPMA Hydrogel Immobilized with Neurite-Promoting Peptides in Traumatic Brain Injury of Adult Rat Model

Published:2003-11 Issue:6 Volume:18 Page:413-432
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Cui F. Z.,Tian W. M.,Fan Y. W.¹,Hou S. P.,Xu Q. Y.²,Lee I.-S.³

Affiliation:

1. Biomaterials Laboratory Department of Materials Science & Engineering Tsinghua University Beijing, 100084, China

2. Beijing Institute of Neuroscience Capital University of Medical Sciences Beijing, 100054, China

3. Atomic-scale Surface Science Research Center, Yonsei University, Seoul, 120-749 Korea

Abstract

A poly[N-(2-hydroxypropyl) methacrylamide] (PHPMA) hydrogel immobilized with the neurite-promoting peptide sequence of xIKVAVx was synthesized and its structure was characterized. The PHPMA-IKVAV hydrogel displayed an interconnected porous structure. The ability of the hydrogel to support axonal outgrowth in the injured adult rats cerebrum cavity and to promote tissue regeneration was evaluated. After implantation for 4, 6, 12 and 18 weeks, the brain sections were processed for histological staining. The observations of the sections showed that the polymer hydrogel provided a structural, three-dimensional continuity across the defect and favoured reorganization of local wound-repair cells, angiogenesis and axonal growth into the hydrogel scaffold. Compared with the unmodified PHPMA hydrogel, the PHPMA-IKVAV hydrogel displayed greater ability to repair tissue defects in the cerebrum nervous system.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0883911503040470

Reference37 articles.

1. 1. Schwab, M.E. (1991). Nerve Fibre Regeneration after Traumatic Lesions of the CNS; Progress and Problems, Phil. Trans. R. Soc. Lond. 331: 303–306 .

2. 3. Bellamkonda, R., Ranieri, J.P. and Aebischer, P. (1995). Laminin Oligopeptide Derivatized Agrose Gels Allow Three-dimensional Neurite Extension In Vitro, J. Neurosci. Res., 41: 501–509 .

3. 4. Krewson, C.E., Chung, S.W., Dai, W. and Saltzman, M.W. (1986). Cell Aggregation and Neurite Growth in Gels of Extracellular Matrix Molecules, Biotechnol . Bioengineering, 43: 555–562 .

4. Collagen-GAG Substrate Enhances the Quality of Nerve Regeneration through Collagen Tubes up to Level of Autograft

5. 6. Spilker, M.H., Yannas, I.V., Kostyk, S.K., Norregaard, T.V., Hsu, H.P. and Spector, M. (2001). The Effects of Tubulation on Healing and Scar Formation after Transection of the Adult Rat Spinal Cord, Restor . Neurol. Neurosci., 18(1): 23–38 .

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Neural Tissue Engineering;Neural Engineering;2020

2. Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats;Regenerative Biomaterials;2019-08-05

3. Chondroitin Sulfate Glycosaminoglycans for CNS Homeostasis-Implications for Material Design;Current Medicinal Chemistry;2014-10-30

4. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation;Cell Proliferation;2014-03-12

5. Cytotoxic effect of 4-hydroxytamoxifen conjugate material on human Schwann cells: Synthesis and characterization;Journal of Bioactive and Compatible Polymers;2013-10-16