Antitumoral Activity Induced by Alkylating Agents Conjugated to Poly(maleic anhydride-alt-vinyl acetate)-Reference-Cited by-同舟云学术

Antitumoral Activity Induced by Alkylating Agents Conjugated to Poly(maleic anhydride-alt-vinyl acetate)

Published:2007-11 Issue:6 Volume:22 Page:651-666
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Popa Marcel¹,Sunel Valeriu²,Dulea Nicoleta²,Popa Aura Angelica³,Ottenbrite Raphael M.⁴,Uglea Constantin V.⁵

Affiliation:

1. Department of Natural and Synthetic Polymers, "Gh.Asachi" Technical University of Iaşşi, Bd. D. Mangeron, No 71 A, 700050 Iaşi, Romania,

2. Department of Organic Chemistry, "Al.I.Cuza" University of Iaşi, Bd. Carol No 11, 700506, Iaşşi, Romania

3. "Petre Andrei" University, Str. Ghica Voda, No. 13, 700400, Iasi, Romania

4. Virginia Commonwealth University, Richmond, USA

5. Department of Biomedical Engineering, University of Medicine and Pharmacy, Str. Universitatii 16, 700015 Iasi, Romania

Abstract

New polyanionic polymer conjugates with antitumoral activity are synthesized by chemically binding mustard type alkylating derivatives of di-(β-chloroethyl)-amine and tri-(β-chloroethyl)-amine, respectively, onto poly(maleic anhydride-alt-vinyl acetate). The structures of the compounds are verified by FTIR, 1H NMR, and elemental analysis. The antitumoral activity of these polymeric drugs is evaluated in vivo using carcinosarcoma Walker 256 solid tumors in Wister rats. The conjugates exhibit antitumor regression (ATR) values between 25 and 44% depending on comonomers' structure. In addition, an accumulation in the solid tumors (enhanced permeability and retention (EPR) effect) by these compounds is observed. These compounds also cause small organotropic effects, such as increases in the liver, spleen, and kidney weight.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0883911507084424

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