Synthesis, Physico-Chemical Properties and Immunoadjuvant Activity of Water-Soluble Phosphazene Polyacids-Reference-Cited by-同舟云学术

Synthesis, Physico-Chemical Properties and Immunoadjuvant Activity of Water-Soluble Phosphazene Polyacids

Published:1998-10 Issue:4 Volume:13 Page:243-256
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Andrianov Alexander K.¹,Sargent Jonathan R.¹,Sule Sameer S.¹,Le Golvan Mark P.¹,Woods Angela L.¹,Jenkins Sharon A.¹,Payne Lendon G.¹

Affiliation:

1. Virus Research Institute, Inc., 61 Moulton St., Cambridge, MA 02138

Abstract

Mixed-substituted polyphosphazenes containing carboxylic acid and alkyl ether side groups were synthesized and characterized. Physicochemical properties of phosphazene polyacids in aqueous solutions were investigated as a function of copolymer structure and composition. The immunoadjuvant activity of polyphosphazenes was evaluated by studying the effect of copolymers on the immunogenicity of the influenza virus in mice. Synthesized polyphosphazenes demonstrated the ability to enhance the immune response as compared to the levels elicited by the vaccine alone.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391159801300401

Reference13 articles.

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