Calendula officinalis extract-loaded conduits improved sciatic nerve injury repair through upregulation of BDNF and GFAP-Reference-Cited by-同舟云学术

Calendula officinalis extract-loaded conduits improved sciatic nerve injury repair through upregulation of BDNF and GFAP

Published:2024-06-22 Issue:4 Volume:39 Page:217-235
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Xu Feng¹²,Su GuiBin³⁴^ORCID

Affiliation:

1. School of Physical Education and Sports, Southwest Medical University/Research Centre for Exercise and Health Promotion, Southwest Medical University, Luzhou, Sichuan, China

2. Kunsan National University, Kunsan, Jeollabuk-do, South Korea

3. Harbin Sport University, HarBin, Heilongjiang, China

4. Mudanjiang Normal University, Mudanjiang, Heilongjiang, China

Abstract

In the current research, the nanofibrous neural channels were produced by electrospinning of PCL/Gelatin solution loaded with Calendula officinalis extract. The produced scaffolds properties were studied using various in vitro characterization methods. Then, the conduits’ healing potential was investigated in a rat model of PNS injury. In vitro results showed that scaffolds were not toxic and quenched DPPH free radicals. In addition, the extract-loaded conduits exhibited significant anti-inflammatory activity. In vivo study showed that the regular treadmill exercise significantly improved the healing efficacy of the Calendula officinalis-delivering conduits by upregulating BDNF and GFAP proteins.

Funder

Research on the application and demonstration of key technology enhancement methods and results for athletes in winter sports

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/08839115241258150

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