Hydrophilic and Hydrophobic Polymeric Derivatives of Anti-Inflammatory Agents Such as Alclofenac, Ketoprofen, and Ibuprofen-Reference-Cited by-同舟云学术

Hydrophilic and Hydrophobic Polymeric Derivatives of Anti-Inflammatory Agents Such as Alclofenac, Ketoprofen, and Ibuprofen

Published:1991-04 Issue:2 Volume:6 Page:129-141
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Giammona Gaetano¹,Carlisi Bianca¹,Pitarresi Giovanna¹,Fontana Giacomo¹

Affiliation:

1. Dipartimento di Chimica e Tecnologie Farmaceutiche Universita'di Palermo via Archirafi 32 90123 Palermo (Italy)

Abstract

Macromolecular prodrugs of a hydrophilic polymer [α,β-poly( N- hydroxyethyl)-DL-aspartamide (PHEA)] was used as a drug carrier. Three poly- (HEA)-NSAID adducts were studied: poly(HEA)-Alclofenac, poly(HEA)-Keto profen, and poly(HEA)-Ibuprofen. Prodrugs with different drug content were synthesized both as water-soluble and water-insoluble agents. Hydrolysis of water-soluble adducts in a simulated gastric juice was studied.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391159100600202

Reference27 articles.

1. Absorption, distribution and toxicity of ibuprofen

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3. Regeneration characteristics of mitomycin C-dextran conjugate in relation to its activity.

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