Review : Polymer Drugs and Polymeric Drugs: Part 3-Synthesis and Hydrolysis of Acryloyl and Methacryloyl Type Polymeric Drugs Containing 5-Fluorouracil and Theophylline-Reference-Cited by-同舟云学术

Review : Polymer Drugs and Polymeric Drugs: Part 3-Synthesis and Hydrolysis of Acryloyl and Methacryloyl Type Polymeric Drugs Containing 5-Fluorouracil and Theophylline

Published:1987-04 Issue:2 Volume:2 Page:120-130
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Akashi Mitsuru¹,Tanaka Yasuo¹,Miyazaki Tsuyoshi¹,Miyauchi Noriyuki¹

Affiliation:

1. Department of Applied Chemistry Faculty of Engineering Kagoshima University 1-21-40 Korimoto, Kagoshima 890, Japan

Abstract

Acryloyl and methacryloyl derivatives of 5-fluorouracil and theophylline were synthesized by the reaction of trimethylsilylated 5-fluorouracil or theophylline with acryloyl chloride or methacryloyl chloride. Polymerization and copoly merization of derivatives with vinyl monomers gave polymeric drugs contain ing pharmaceutically active 5-fluorouracil or theophylline. Under mild conditions, these acryloyl and methacryloyl type polymeric drugs were found to undergo amide hydrolysis to release the 5-fluorouracil or theophylline.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391158700200202

Reference13 articles.

1. Takemoto, K. Polymeric Drugs. L. G. Donaruma and O. Vogl, eds. New York: Academic Press, p. 103 (1978).

2. Pitha, J., M. Akashi and M. Draminski. Biomedical Polymer: Polymeric Materials and Pharmaceuticals for Biomedical Use. E. P. Goldberg and A. Nakajima, eds. New York :Academic Press, p. 271 (1978).

3. Synthesis and Properties of Hydrophilic Copolymers Containing 5-Fluorouracil, Thymine, or Adenine

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Application of 2-hydroxyethyl methacrylate polymers in controlled release of 5-aminosalicylic acid as a colon-specific drug;Journal of Polymer Research;2007-01-20

2. Synthesis and study of controlled release of ibuprofen from the new acrylic type polymers;International Journal of Pharmaceutics;2006-06

3. Release of 5-amino salicylic acid from acrylic type polymeric prodrugs designed for colon-specific drug delivery;Journal of Controlled Release;1999-04

4. Polymer Drugs and Polymeric Drugs IX. Synthesis and 5-Fluorouracil Release Profiles of Biodegradable Polymeric Prodrugs γ-Poly(α-Hydroxymethyl-5-Fluorouracil-Glutamate);Journal of Bioactive and Compatible Polymers;1998-07

5. Acrylic type polymers containing ibuprofen and indomethacin with difunctional spacer group: synthesis and hydrolysis;Journal of Controlled Release;1997-07