New biodegradable drug-eluting stents for urethral strictures in a rabbit model

Abstract

In this study, the feasibility and the effect of a new biodegradable drug-eluting urethral stents for the treatment of urethral stricture in a rabbit model were evaluated, and the biocompatibility properties of the new biodegradable drug-eluting urethral stents in the rabbit urethral assessed. A total of 34 male New Zealand White rabbits with urethral strictures were used, and equally divided into two groups: with drug stents and drug-free stents. The urethral strictures were made by using a self-control explosion device as the control. Stents were surgically implanted into the stenotic urethras of rabbits under direct vision. Reparative effects, including biocompatibility assessment, were evaluated by urethroscopy, retrograde urethrography, and histology at different intervals at weeks 4, 8, and 12. Although retrograde urethrography and urodynamic results at 12 weeks showed no comparable differences among the three groups, urethroscopic and histological follow-up indicated that the drug stents had minimized the stent-related inflammatory responses, urothelial hyperplasia, and scar formation compared with the drug-free stents. The new biodegradable paclitaxel-eluting stents were more biocompatible and effective for treating urethral strictures in the rabbit model than the drug-free stents.