A Convenient Method for the Synthesis of (S)-Dolichol and (S)-Nordolichol

Abstract

A procedure for the preparation of (S)-dolichol and (S)-nor-dolichol starting from the polyprenyl fraction extracted from Gingko Biloba integer or extracted leaves is described. Two chiral isoprenoid compounds in good yields and high degree of enantiomeric excess were obtained. The (S)-nordolichol appears to be a good chiral precursor for the preparation of 14C-labeled (S)-dolichol which is to be used in investigations aimed at gaining further information with respect to the role of dolichol in the function of living cells.