Poly(ester-anhydride) for controlled delivery of hydrophilic drugs-Reference-Cited by-同舟云学术

Poly(ester-anhydride) for controlled delivery of hydrophilic drugs

Published:2015-08-19 Issue:2 Volume:31 Page:127-139
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Ickowicz Diana E¹,Abtew Ester¹,Khan Wahid¹²,Golovanevski Ludmila³,Steinman Noam¹,Weiniger Carolyn F³⁴,Domb Abraham J¹

Affiliation:

1. Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

2. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India

3. Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel

4. Stanford School of Medicine, Stanford, CA, USA

Abstract

Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70 w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28 days.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0883911515598796

Reference31 articles.

1. Polymeric implants for cancer chemotherapy

2. Toxicity, biodegradation and elimination of polyanhydrides

3. In Vivo Degradation and Elimination of Injectable Ricinoleic Acid-Based Poly(ester-anhydride)

4. Controlled release of a local anesthetic from fatty acid dimer based polyanhydride

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