Affiliation:
1. Department of Pharmaceutics and Center for Controlled Chemical Delivery University of Utah Salt Lake City, Utah 84112, USA
Abstract
Biodegradable poly(α-amino acids) can serve as chemical carriers of active agents. The narcotic antagonist naltrexone and the anti-hypertensive minox idil were covalently coupled to polymer backbones based upon L-glutamic acid to give polymeric prodrugs. The synthesis and release characteristics of these two systems are reviewed. The rate of hydrolytic cleavage of the polymer-drug linkage should be much slower than the rate of diffusion through the polymer matrix; thus release rates approaching zero order can be achieved. In vitro and in vivo release studies demonstrate the potential for these types of polymeric delivery systems.
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献