Poly(vinyl alcohol)-based electrospun meshes as potential candidate scaffolds in regenerative medicine-Reference-Cited by-同舟云学术

Poly(vinyl alcohol)-based electrospun meshes as potential candidate scaffolds in regenerative medicine

Published:2010-12-05 Issue:1 Volume:26 Page:20-34
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Puppi Dario¹,Piras Anna Maria¹,Detta Nicola¹,Ylikauppila Hanna²,Nikkola Lila²,Ashammakhi Nureddin²,Chiellini Federica¹,Chiellini Emo³

Affiliation:

1. Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), Department of Chemistry and Industrial Chemistry, University of Pisa, via Vecchia Livornese 1291, 56010 San Piero a Grado (Pi), Italy

2. Department of Biomedical Engineering, Tampere University of Technology, PO Box 589 (Hermiankatu 12 B), FIN-33101 Tampere, Finland

3. Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), Department of Chemistry and Industrial Chemistry, University of Pisa, via Vecchia Livornese 1291, 56010 San Piero a Grado (Pi), Italy,

Abstract

Fibrous meshes based on three different poly(vinyl alcohol) (PVA) polymers, with 12% vinyl acetate monomeric units and molar weights of 37,000, 67,000, and 130,000 were developed as potential scaffolds for regenerative medical applications. The meshes were electrospun and characterized by molecular weight, concentration, applied voltage, and needle—collector distance. The influence of feed rate and the electrodes configuration (needle-to-tip and screen-to-screen system) was determined. Highly porous, 3D structures composed of randomly oriented ultrafine fibers, with an average fiber diameter of a few hundred nanometers were developed. Solutions of PVA and human serum albumin were successfully electrospun and the fibrous mesh was stabilized with glutaraldehyde. The influence of these operations on the mechanical properties was evaluated by uniaxial tensile testing.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0883911510392007

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