Polypharmacy of Older Surgical Patients With Extremity Fractures

Author:

Taniguchi Takumi1,Inagaki Risa2,Michikawa Takehiro3,Kawabata Soya1,Yoshida Masahiro4,Kawano Yusuke1,Morita Mitsuhiro1,Hayakawa Kazue1,Iwata Mitsunaga5,Yamada Shigeki2,Fujita Nobuyuki1ORCID

Affiliation:

1. Department of Orthopaedic Surgery, School of Medicine, Fujita Health University, Aichi, Japan

2. Department of Clinical Pharmacy, School of Medicine, Fujita Health University, Aichi, Japan

3. Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan

4. Department of Orthopaedic Surgery, School of Medicine, Aichi Medical University, Aichi, Japan

5. Department of Emergency and General Internal Medicine, School of Medicine, Fujita Health University, Aichi, Japan

Abstract

Introduction Fractures are often caused by falls in older people. Among various causes of falls, polypharmacy is known to be a risk of falls. Furthermore, potentially inappropriate medicines (PIMs), which interact with polypharmacy, include the drugs involved in falls. Here, we primarily aimed to investigate the prescribed drugs in older surgical patients with extremity fractures to determine the frequency of polypharmacy and identify PIMs. The second aim was to clarify the characterization of prescribed drugs of older patients with hip fracture. Materials and Methods We retrospectively collected the following clinical data of consecutive patients aged ≥65 years who underwent surgery for extremity fractures at our hospital between April 2019 and March 2021. A total of 19 categories were considered as PIMs. The Poisson regression models were used to examine the association between the number of prescribed drugs and hip fracture prevalence. Results A total of 590 patients were reviewed. Our data showed that 55% of older patients with extremity fractures took ≥6 prescription drugs. The frequency of prescription of hypnotics, antithrombotic drugs, diuretics, and non-steroidal anti-inflammatory drugs was comparatively high among the 19 categories of PIMs. Multivariable analysis revealed that polypharmacy was significantly associated with hip fractures. Among PIMs, antithrombotic drugs and diuretics were significantly associated with the prevalence of hip fractures. Finally, we found a significant positive association between the prevalence of hip fracture and the number of drug categories of PIMs among older patients with extremity fractures. Conclusions The present study clarified the characterization of the prescribed drugs in older surgical patients with extremity fractures. Special attention should be paid to hip fractures of older patients with polypharmacy or prescribed with many drugs categories of PIMs, particularly antithrombotic drugs and diuretics.

Publisher

SAGE Publications

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