Affiliation:
1. FSBSI “Chumakov FSC R&D IBP RAS”, Moscow, Russia
2. Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia
3. Sechenov First Moscow State Medical University, Moscow, Russia *The work on the basis of the FSBSI “Chumakov FSC R&D IBP RAS” was performed by the author during her employment from 2012 to 2017
Abstract
Tick-borne encephalitis is an important human arbovirus neuroinfection spread across the Northern Eurasia. Inhibitors of tick-borne encephalitis virus (TBEV) strain Absettarov, presumably targeting E protein n-octyl-β-d-glucoside (β-OG) pocket, were reported earlier. In this work, these inhibitors were tested in vitro against seven strains representing three main TBEV subtypes. The most potent compound, 2-[(2-methyl-1-oxido-5,6,7,8-tetrahydroquinazolin-4-yl)amino]-phenol, showed EC50 values lower than 22 µM against all the tested strains. Nevertheless, EC50 values for virus samples of certain strains demonstrated a substantial variation, which appeared to be consistent with the presence of E protein not only in infectious virions, but also in non-infectious and immature virus particles, protein aggregates, and membrane complexes.
Funder
Russian Foundation for Basic Research
Cited by
12 articles.
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