Therapeutic Vaccine against Streptococcus sobrinus-induced Caries-Reference-Cited by-同舟云学术

Therapeutic Vaccine against Streptococcus sobrinus-induced Caries

Published:2004-04 Issue:4 Volume:83 Page:354-358
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Dinis M.¹²³⁴⁵,Tavares D.¹²³⁴⁵,Fonseca A.J.M.M.¹²³⁴⁵,Faria R.¹²³⁴⁵,Ribeiro A.¹²³⁴⁵,Silvério Cabrita A.M.¹²³⁴⁵,Ferreira P.¹²³⁴⁵

Affiliation:

1. Laboratory of Immunology, ICBAS-Instituto de Ciências Biomédicas de Abel Salazar, Lg. Prof. Abel Salazar 2, 4099-003 Porto,

2. Instituto de Biologia Molecular e Celular, Porto,

3. Faculdade de Medicina de Coimbra-Hospitais da Universidade de Coimbra, and

4. Faculdade de Medicina de Coimbra -Instituto de Patologia Experimental-, Coimbra, Portugal;

5. authors contributing equally to this work;

Abstract

Streptococcus sobrinus produces a virulence-associated immunomodulatory protein (VIP) which suppresses the host-specific immune response and induces the early production of IL-10. In this study, we evaluated the effects of therapeutic immunization with this VIP on the incidence of caries in S. sobrinus-infected rats. Groups of Wistar rats were orally infected with S. sobrinus and fed with sucrose-sweetened drinking water ad libitum. Five days later, rats were immunized intranasally with active or heat-inactivated VIP plus alum as adjuvant or PBS plus adjuvant (sham-immunized). After 3 wks, all rats were re-immunized as above. Evaluation of dental caries showed that VIP-immunized animals had significantly fewer enamel sulcal and proximal caries lesions than did the sham-immunized animals (p < 0.001). The protective effects following therapeutic VIP immunization were attributed to the induced salivary immunoglobulin A specific to the VIP. These results offer a promising and safe strategy for the development of a vaccine against dental caries.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/154405910408300416

Reference29 articles.

1. Is Prophylactic Immunostimulation of the Host against Pathogenic Microbial Antigens an Adequate Strategy of Immunoprotection?

2. Evidence for the synthesis and release of strongly immunosuppressive, noncytotoxic substances by Streptococcus intermedius.

3. Arala-Chaves MP, Ribeiro Ajos S, Vilanova M, Porto MT, Santarém MG, Lima M -1988- Correlation between B-cell mitogenicity and immunosuppressor effects of a protein released by porcine monocyte infected with African swine fever virus. Am J Vet Res 49:1955–1961.

4. Blander SJ, Horwitz MA -1991- Vaccination with the major secretory protein of Legionella induces humoral and cell-mediated immune responses and protective immunity across different serogroups of Legionella pneumophila and different species of Legionella. J Immunol 147:285–291.

5. Caufield PW -1997- Dental caries—a transmissible and infectious disease revisited: a position paper. Pediatr Dent 19:491–498.

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Flagellin-PAc Fusion Protein Inhibits Progression of Established Caries;Journal of Dental Research;2015-04-16

2. Quantitative analysis of changes in salivary mutans streptococci after orthodontic treatment;American Journal of Orthodontics and Dentofacial Orthopedics;2014-05

3. References;Pathology of the Hard Dental Tissues;2013-04-05

4. rEnolase Maternal Immunization Confers Caries Protection on Offspring;Journal of Dental Research;2011-02-04

5. Genetic Immunization Converts the Trypanosoma cruzi B-Cell Mitogen Proline Racemase to an Effective Immunogen;Infection and Immunity;2010-02