Gingival Tissue and Crevicular Fluid Co-operation in Adult Periodontitis

Author:

Beklen A.12345,Tüter G.12345,Sorsa T.12345,Hanemaaijer R.12345,Virtanen I.12345,Tervahartiala T.12345,Konttinen Y.T.12345

Affiliation:

1. Department of Medicine/Invärtes medicin, Helsinki University Hospital, Biomedicum Helsinki, PO Box 700 -Haartmaninkatu 8-, FIN-00029 HUS, Helsinki, Finland;

2. Institute of Biomedicine/Anatomy, University of Helsinki, Helsinki, Finland;

3. Medico-social, Dental Clinic, Bogazici University, Istanbul, Turkey;

4. Department of Oral and Maxillofacial Diseases, HUCH, Institute of Dentistry, University of Helsinki, Box 41 FIN-00014 Helsinki, Finland;

5. University of Gazi, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey;

Abstract

Activated matrix metalloproteinase-3 (MMP-3) can contribute to periodontal ligament destruction in adult periodontitis. Since MMP-3 has been reported to activate proMMP-8 and -9, it was speculated that gingival tissue fibroblast-derived MMP-3 might, in periodontitis, be responsible for activation of gingival crevicular fluid (GCF) neutrophil-derived proMMP-8 and -9. Immunohistochemistry disclosed MMP-3 in gingival fibroblasts in periodontitis. Cultured gingival fibroblasts released only pro-MMP-3 when stimulated with tumor necrosis factor-α. However, Western blot revealed partially activated MMP-3, MMP-8, and MMP-9 in periodontitis GCF. Active MMP-8 (p < 0.05) and MMP-9 (p < 0.05) correlated with the presence of active MMP-3. It seems that resident gingival fibroblasts produce pro-MMP-3 in GCF, where it becomes activated, probably by cathepsin G or elastase released by neutrophils. Active MMP-3 then activates neutrophil-derived pro-MMP-8 and -9. Different tissue compartments/cells exert co-operative actions in mutual local MMP activation cascades.

Publisher

SAGE Publications

Subject

General Dentistry

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