Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells-Reference-Cited by-同舟云学术

Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

Published:2009-09 Issue:3 Volume:7 Page:183-190
ISSN:2058-7392
Container-title:European Journal of Inflammation
language:en
Short-container-title:Eur J Inflamm

Author:

Castellani M.L.¹,Toniato E.¹,Felaco P.²,Ciampoli C.³,De Amicis D.⁴,Orso C.⁴,Cucurullo C.⁵,Vecchiet J.⁶,Tetè S.⁷,Salini V.⁴,Caraffa A.⁸,Pandolfi F.⁹,Antinolfi P.L.⁸,Cerulli G.⁸,Conti F.¹⁰,Fulcheri M.¹¹,Sabatino G.¹²,Boscolo P.¹³,Shaik Y.B.¹⁴

Affiliation:

1. Immunology Division, University of Chieti, Chieti, Italy

2. Division of Nephrology, University of Chieti, Chieti, Italy

3. Clinic of Infectious Diseases, Medical School, University of Chieti-Pescara, Chieti, Italy

4. Department of Human Dynamics, University of Chieti-Pescara, Italy

5. Division of Medical Pathology, University of Chieti, Italy

6. Clinical of Infectious Diseases, Medical School, University of Chieti-Pescara, Chieti, Italy

7. Dental School, University of Chieti-Pescara, Chieti, Italy

8. Orthopaedics Division, University of Perugia, Perugia, Italy

9. Catholic University, Rome, Italy

10. Gynecology Division, University of Chieti, Chieti, Italy

11. Department of Clinical Psychology, University of Chieti-Pescara, Italy

12. Department of Paediatrics, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy

13. Department of Biomedical Science, University of Chieti, Chieti, Italy

14. Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Abstract

IL-32 is onae of the last important cytokines discovered, produced mainly by T cells, natural killer cells, and epithelial cells. Probably many other different cells are a source of IL-32, which has been found to be a powerful pro-inflammatory mediator. Here we studied the effect of IL-32 on histamine release by human-derived cord-blood mast cells. In these studies we found that IL-32 significantly stimulates the release of histamine only at high concentrations (100 ng/ml) while at 10 or 50 ng/ml it had no effect. These results were found for the first time and demonstrate that IL-32 may play an important role in allergic and inflammatory diseases.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/1721727X0900700309

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