Impact of Immunity in Autism Spectrum Disorders

Author:

Tetè S.1,Varvara G.1,Murmura G.1,Saggini A.2,Maccauro G.3,Rosati M.4,Cianchetti E.5,Tripodi D.1,Toniato E.6,Fulcheri M.7,Caraffa A.8,Antinolfi P.8,Pandolfi F.9,Potalivo G.8,Conti P.6,Theoharides T.C.10

Affiliation:

1. Dental School, University of Chiet-Pescarai, Chieti, Italy

2. Dermatology Department, University Tor Vergata, Rome, Italy

3. Orthopedics Division, Università Cattolica, Rome, Italy

4. Gynecology Division, Pescara Hospital, Italy

5. Department of Surgery, Ortona ASL Hospital, Ortona, Italy

6. Immunology Division, Medical School, University of Chieti-Pescara, Italy

7. Psychology School, University of Chieti-Pescara, Italy

8. Orthopeadics Division, University of Perugia, Italy

9. Department of Medicine, Catholic University of Rome, Rome, Italy

10. Internal Medicine and Biochemistry, Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine and Drug Discovery Laboratory, Tufts-New England Medical Center, Boston, MA, USA

Abstract

Autism spectrum disorders (ASDs) are childhood psychopathologies characterized by having difficulties in social interaction, verbal and non-verbal communication as well as sensor motor movements. Evidence suggests that in ASDs environmental toxicant exposure, genetic and mitochondrial dysfunction are involved associated with abnormal immune response with allergic problems and elevated serum IgE. ASDs present the major cytokine and chemokine dysfunction in CNS and is mediated by an increase of pro-inflammatory cytokine levels in the brain, such as TNF, IL-1, IFN-γ, IL-6, IL-8 and others. Mast cells, which are also implicated in ASDs, are worsened by stress and produce proinflammatory cytokines and can be stimulated by neurotensin in the brain and gut, contributing also to the inflammatory response. However, the exact etiology of ASDs remains largely unknown.

Publisher

SAGE Publications

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3