Association between IL-25, IL-33 and atopic dermatitis: A systematic review and meta-analysis

Author:

Zhou Boyang1ORCID,Yue Xueping2,Liang Surong1,Shang Shuai1,Xiang Lujing1,Zhou Kefei1,Li Linfeng1ORCID

Affiliation:

1. Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

2. Department of Dermatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Abstract

Objective: To evaluate the association between IL-25, IL-33 and AD more generally. Methods: Databases, including PubMed, Web of Science, EMBASE, Scopus, CNKI and Sinomed were searched. Based on the criteria, publications were collected. The evaluation of study quality was through Newcastle-Ottawa Scale (NOS). Fixed or random effect model was selected according to the between-study heterogeneity to evaluate the association. The analysis procedure and the construction plots were using Review Manager 5.3 software. Results: Six studies were included. A total of 282 subjects were included from four studies to analyze the association between IL-25 and AD. The level of IL-25 was significantly elevated in AD patients, comparing with the control subjects (SMD = 0.89, 95% CI: 0.64, 1.14, p < 0.05). For IL-33, a total of 247 subjects were included from two studies, and the level of IL-33 was also significantly elevated in AD patients comparing to the control subjects (SMD = 0.49, 95% CI: 0.19, 0.80, p < 0.05). Conclusions: The serum levels of IL-25, IL-33 are elevated in AD patients of this study. The IL-25 and IL-33 are significantly associated with the risk of AD. Further studies with larger samples, in multiple countries and focused on different age groups are need.

Funder

Natural Science Foundation of Beijing Municipality

Publisher

SAGE Publications

Subject

Immunology,Immunology and Allergy,General Medicine

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