Antiviral activity of sirolimus in an HIV-positive kidney transplant recipient-Reference-Cited by-同舟云学术

Antiviral activity of sirolimus in an HIV-positive kidney transplant recipient

Published:2019-07-07 Issue:9 Volume:30 Page:919-922
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Alfano Gaetano¹²^ORCID,Fontana Francesco¹²,Mori Giacomo¹,Vicari Emanuela²,Dolci Giovanni³,Franceschini Erica³,Guaraldi Giovanni³,Mussini Cristina³,Cappelli Gianni¹²

Affiliation:

1. Nephrology Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy

2. Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy

3. Clinic of Infectious Diseases, University of Modena and Reggio Emilia, University Hospital of Modena, Modena, Italy

Abstract

Sirolimus (SIR) is a potent immunosuppressive agent with multiple proprieties. We report beneficial antiviral effects of SIR in an HIV-positive kidney transplant recipient who experienced low-level HIV-1 replication. The immunosuppressive agent was well tolerated by the patient, and no side effects were reported during follow-up. Despite immunosuppressive monotherapy, SIR ensured stable graft function.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0956462419839520

Reference21 articles.

1. Sirolimus in renal transplantation

2. Immunoregulatory functions of mTOR inhibition

3. Potential use of rapamycin in HIV infection

4. Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatment

5. Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immunological Results of Long-Term Use of Mammalian Target of Rapamycin (mTOR) Inhibitors and Its Effects on Renal Graft Functions;Annals of Transplantation;2021-07-30

2. Interferon-inducer antivirals: Potential candidates to combat COVID-19;International Immunopharmacology;2021-02

3. COVID-19 Treatment: Drug Safety Prior to Conception and During Pregnancy and Breastfeeding;Geburtshilfe und Frauenheilkunde;2021-01

4. Initial dose recommendation for sirolimus in paediatric kaposiform haemangioendothelioma patients based on population pharmacokinetics and pharmacogenomics;Journal of International Medical Research;2020-08

5. Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient;International Journal of STD & AIDS;2020-02-19