Partner notification and treatment outcomes among South African adolescents and young adults diagnosed with a sexually transmitted infection via laboratory-based screening

Author:

Chitneni Pooja1ORCID,Beksinska Mags2,Dietrich Janan J3,Jaggernath Manjeetha2,Closson Kalysha4,Smith Patricia4,Lewis David A5678,Matthews Lynn T9,Smit Jenni2,Ndung’u Thumbi101112,Brockman Mark4,Gray Glenda313,Kaida Angela4,

Affiliation:

1. Brigham and Women’s Hospital and Massachusetts General Hospital combined Infectious Diseases Fellowship, Boston, USA

2. Maternal Adolescent and Child Health (MatCH) Research Unit (MRU), Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa

3. Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

4. Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada

5. Westmead Clinical School, Westmead, Australia

6. Faculty of Medicine and Health, University of Sydney, Sydney, Australia

7. Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia

8. Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

9. Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, USA

10. HIV Pathogenesis Programme and Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa

11. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, USA

12. Max Planck Institute for Infection Biology, Berlin, Germany

13. South African Medical Research Council, Cape Town, South Africa

Abstract

Partner notification and treatment are essential components of sexually transmitted infection (STI) management, but little is known about such practices among adolescents and young adults. Using data from a prospective cohort study (AYAZAZI) of youth aged 16–24 years in Durban, South Africa, we assessed the STI care cascade across participant diagnosis, STI treatment, partner notification, and partner treatment; index recurrent STI and associated factors; and reasons for not notifying partner of STI. Participants completed laboratory-based STI screening ( Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis) at enrollment and at 12 months. Of the 37/216 participants with STI (17%), 27/37 (73%) were women and 10/37 (27%) were men. Median age was 19 years (IQR: 18–20). Of the participants with STI, 23/37 (62%) completed a Treatment and Partner Tracing Survey within 6 months of diagnosis. All survey participants reported completing STI treatment (100%), 17/23 (74%) notified a partner, and 6/23 (35%) reported partner treatment. Overall, 4/23 (11%) participants had 12-month recurrent C. trachomatis infection, with no association with partner notification or treatment. Stigma and lack of STI knowledge were reasons for not notifying partner of STI. STI partner notification and treatment is a challenge among youth. Novel strategies are needed to overcome barriers along the STI care cascade.

Funder

Wellcome Trust

New Partnership for Africa's Development

African Academy of Sciences

National Institute of Allergy and Infectious Diseases

Sub-Saharan African Network for TB/HIV Research Excellence

Canada Research Chairs

National Institute of Mental Health

Fogarty International Center

South Africa Research Chairs Initiative

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

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