Individual and partner risk factors associated with abnormal cervical cytology among women in HIV-discordant relationships-Reference-Cited by-同舟云学术

Individual and partner risk factors associated with abnormal cervical cytology among women in HIV-discordant relationships

Published:2013-09-18 Issue:5 Volume:25 Page:315-324
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Soh Jason¹²,Rositch Anne F³,Koutsky Laura²,Guthrie Brandon L²⁴,Choi Robert Y⁵,Bosire Rose K⁶,Gatuguta Ann⁷,Smith Jennifer S⁸,Kiarie James⁹,Lohman-Payne Barbara⁴¹⁰,Farquhar Carey²⁴⁵

Affiliation:

1. School of Medicine, Virginia Commonwealth University, Richmond, VA, USA

2. Department of Epidemiology, University of Washington, Seattle, WA, USA

3. Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA

4. Department of Global Health, University of Washington, Seattle, WA, USA

5. Department of Medicine, University of Washington, Seattle, WA, USA

6. Centre for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya

7. School of Public Health, Kenyatta University, Nairobi, Kenya

8. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA

9. Department of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya

10. Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya

Abstract

Individual and sexual partner characteristics may increase the risk of abnormal cervical cytology among women in human immunodeficiency virus (HIV)-discordant relationships. Papanicolaou smears were obtained in a prospective cohort of Kenyan HIV-discordant couples. Of 441 women, 283 (64%) were HIV-infected and 158 (36%) were HIV-uninfected with HIV-infected partners. Overall, 79 (18%) had low-grade and 25 (6%) high-grade cervical abnormalities. Male herpes simplex virus type 2 (HSV-2) seropositivity and lower couple socioeconomic status were associated with cervical abnormalities ( p < 0.05). HIV-uninfected women with HIV-infected male sex partners (CD4 > 350 cells/µL) had the lowest prevalence of high-grade cervical lesions. HIV-infected women (CD4 > 350 cells/µL) and HIV-uninfected women with HIV-infected partners (CD4 ≤ 350 cells/µL) were at similar intermediate risk ( p > 0.05), and HIV-infected women (CD4 ≤ 350 cells/µL) had significantly higher risk of high-grade cervical abnormalities ( p = 0.05). Women in HIV-discordant relationships have high rates of cervical lesions and this may be influenced by couple-level factors, including HIV status and CD4 count of the infected partner.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0956462413504554

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