Association between CD4 lymphocyte count and the incidence of comorbidities in Human immunodeficiency virus positive patients with virological suppression after antiretroviral treatment

Author:

Galeano Adriana C1ORCID,Rincón-Rodríguez CJ2,Gil Fabián2ORCID,Valderrama-Beltrán S3

Affiliation:

1. School of Medicine, Pontificia Universidad Javeriana, Bogotá, DC, Colombia

2. Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, DC, Colombia

3. Division of Infectious Diseases, Hospital Universitario San Ignacio, Bogotá, DC, Colombia

Abstract

Background The incidence of comorbidities is higher in HIV-positive patients than in the general population due to factors, such as HIV-related chronic inflammation. There is no consensus on whether a low CD4 lymphocyte count after virological suppression at long-term follow-up increases the risk of comorbidities. This study evaluates the association between CD4 lymphocyte count and the incidence of comorbidities during the first 5 years of virological suppression after highly active antiretroviral treatment. Methods We conducted a cohort study of HIV-positive adults who achieved virological suppression in an HIV program between 2002 and 2016 in Colombia. A generalized equation estimation model was used to estimate the association between CD4 lymphocyte count and the incidence of comorbidities. Results A follow-up period of at least 1 year was completed in 921 HIV-positive patients with virological suppression. We found 71 comorbidities during a maximum of 5 years of follow-up; 41 (59%) were AIDS-defining comorbidities and 19 (46%) of them occurred during the first semester. Thirty cases of non-AIDS- defining comorbidities were diagnosed. We did not find any association between CD4 lymphocyte count and the incidence of comorbidities (OR 0.92, CI 95% 0.45 -1.91 for CD4 201-499 cells/µL vs CD4 ≤200 cells/µL, and OR 0.55, 95% CI 0.21-1.44 for CD4 ≥500 cells/µL vs CD4 ≤200 cells/µL). Conclusion No association was found between CD4 lymphocyte count and the incidence of AIDS-defining or non-AIDS-defining comorbidities in patients with virological suppression. Further studies are needed to assess the risk of comorbidities in this population to design interventions aimed at improving their prognosis.

Publisher

SAGE Publications

Reference32 articles.

1. Geneva. Joint united nations programme on HIV/AIDS 2023. AIDS Data 2023 https://www.drugsandalcohol.ie/39288/1/The_path_that_ends_AIDS_UNAIDS_Global_AIDS_Update_2023.pdf (2023, accessed 5 January 2024).

2. Immunological and virological responses to highly active antiretroviral therapy in a non-clinical trial setting in a developing Caribbean country

3. EACS. Guidelines version 11.0 2021, https://www.eacsociety.org/media/final2021eacsguidelinesv11.0_oct2021.pdf (2021, accessed October 2021).

4. Relationship between CD4 cell count and serious long-term complications among HIV-positive individuals

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3