Multicentre Clinical Trial with Herpes Simplex Virus Vaccine in Recurrent Herpes Infection

Author:

Mastrolorenzo Antonio1,Tiradritti L1,Salimbeni L1,Zuccati G1

Affiliation:

1. STD & AIDS Center, Department of Dermatology, University of Florence, Italy

Abstract

Summary: The aim of this work was to confirm our preliminary clinical and immunological evaluation of the protective effects of a herpes simplex virus (HSV) vaccine derived from killed virus in the treatment of relapsing facial or genital herpes simplex infection. A total of 142 patients were treated with the HSV vaccine and a control group of 50 were treated with intermittent oral acyclovir (ACV). The vaccine reduced annual active disease days in vaccinees to 11.59 (±15.3) after treatment (65.11±31.64 before treatment) compared to 30.4±17.49 days after treatment of the control group patients (71.86±32.5 before treatment).

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

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