Nodular secondary syphilis in three HIV-positive patients: a case series

Author:

Wang Catherine J1ORCID,Leavens Joan2,Thorpe Joseph2,Crew Ashley2,Kim Gene23,Ahronowitz Iris2,Worswick Scott2

Affiliation:

1. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

2. Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

3. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Abstract

Nodular secondary syphilis is an uncommon variant of secondary syphilis. We identified three cases of nodular secondary syphilis at our institution. The first patient presented with a diffuse nodular rash that included his scrotum and penis. The second patient had disseminated skin-colored nodules with serosanguinous crust on his face, trunk, and extremities. The third patient had a pruritic papular and nodular rash with overlying crust. All three patients had a reactive rapid plasma reagin and tested positive for fluorescent treponemal antibody absorption. All were eventually confirmed to be human immunodeficiency virus-positive. Histopathological examination demonstrated inflammatory infiltrate in the dermis composed of lymphocytes, histiocytes, and plasma cells, and treponemal staining highlighted spirochetes in the dermis. The patients were successfully treated with intramuscular penicillin benzathine G. Physicians should be aware of nodular syphilis as a less common cutaneous manifestation of secondary syphilis. Prompt diagnosis of secondary syphilis can expedite resolution of the infection and avoid progression to tertiary syphilis.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Dermoscopy aiding diagnosis of nodular granulomatous secondary syphilis;Indian Journal of Dermatology, Venereology and Leprology;2024-04-29

2. Nodular Syphilis Seen in an HIV-Positive Man: A Case Study;Military Medicine;2023-04-12

3. Dermoscopy is a useful tool in the diagnosis of nodular secondary syphilis;BMJ Case Reports;2022-11

4. A 42-year-old man with nodular skin lesions;Official Journal of the Association of Medical Microbiology and Infectious Disease Canada;2021-07

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