Neurodegeneration, Heterochromatin, and Double-Stranded RNA-Reference-Cited by-同舟云学术

Neurodegeneration, Heterochromatin, and Double-Stranded RNA

Published:2019-01 Issue: Volume:13 Page:117906951983069
ISSN:1179-0695
Container-title:Journal of Experimental Neuroscience
language:en
Short-container-title:J Exp Neurosci

Author:

Saldi Tassa K¹,Gonzales Patrick K²,LaRocca Thomas J²,Link Christopher D²^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO, USA

2. Department of Integrative Physiology, University of Colorado, Boulder, CO, USA

Abstract

Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases.

Funder

National Institute of Neurological Disorders and Stroke

Publisher

SAGE Publications

Subject

General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/1179069519830697

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