Growth Hormone is a Stimulating but Not An Essential Factor in Healing of Colon-Reference-Cited by-同舟云学术

Growth Hormone is a Stimulating but Not An Essential Factor in Healing of Colon

Published:2006-09 Issue:3 Volume:95 Page:205-210
ISSN:1457-4969
Container-title:Scandinavian Journal of Surgery
language:en
Short-container-title:Scand J Surg

Author:

Tei T. M.¹,Kissmeyer-Nielsen P.¹²,Flyvbjerg A.²,Christensen H.¹²

Affiliation:

1. Department of Surgery L, University Hospital of Aarhus; Medical Research Lab M. and

2. Institute of Experimental Clinical Research, University Hospital of Aarhus, Aarhus C, Denmark

Abstract

Background: Growth hormone (GH) has been implicated as an important factor in the healing and previous studies showed significant strength acceleration of experimental intestinal anastomoses. Aim: To study the healing of experimental colonic anastomoses in GH-deficient rats and to study the potential physiological effects of GH-substitution on healing parameters. Conclusion: Exogenous rhGH treatment started 7 days prior to surgery and continued until day 4 postoperatively accelerates the strength development of the experimental colonic anastomoses in dwarf rats indicating a potent role of growth hormone in colonic healing. However, GH is not essential in the healing process, since anastomotic healing in GH-deficient dwarf rats is like rats with normal pituitary function.

Publisher

SAGE Publications

Subject

Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/145749690609500315

Reference21 articles.

1. Anastomotic integrity after operations for large-bowel cancer: a multicentre study.

2. Metabolic response to sepsis and trauma

3. The effect of an intralminal tube used as an internal drain on the healing of the rat colon

4. Metabolic effects of recombinant human growth hormone: Isotopic studies in the postabsorptive state and during total parenteral nutrition

5. Low-Dose Growth Hormone and Hypocaloric Nutrition Attenuate the Protein-Catabolic Response After Major Operation

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Growth hormone abolishes the negative effects of everolimus on intestinal wound healing;World Journal of Gastroenterology;2016

2. Reduced colonic apoptosis in mice overexpressing bovine growth hormone occurs through changes in several kinase pathways;Growth Hormone & IGF Research;2009-10