Modern Management of Colorectal Cancer — A Pathologist's View

Author:

Maughan N. J.1,Quirke P.2

Affiliation:

1. Academic Unit of Pathology, University of Leeds, Leeds, UK

2. Department of Pathology, Algernon Firth Building, Leeds General Infirmary, Leeds, UK

Abstract

Colorectal cancer is an increasingly significant cause of both mortality and morbidity due to wider adoption of the Western lifestyle and a progressively ageing population. Recently steps forward have been made both in surgical and chemoradiotherapeutic management of this disease. Well performed total mesorectal excision surgery has now become the gold standard for rectal cancer resection. Several prognostic markers, both clinicopathological and molecular, have been identified allowing better patient counselling and targeting of treatment. The rationale for patient selection, timing and dose of radiotherapy has been further elucidated. New chemotherapy agents are under trial and predictive factors allowing selection of those patients most likely to respond to them have been identified. Many of these factors will increase in importance as colorectal cancer becomes a chronic disease with lengthening survival times. As we will discuss the pathologist has important roles in all of these developments and at all stages of colorectal cancer management.

Publisher

SAGE Publications

Subject

Surgery

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1. Total neoadjuvant therapy in rectal cancer;memo - Magazine of European Medical Oncology;2022-11-30

2. Association of certification, improved quality and better oncological outcomes for rectal cancer in a specialized colorectal unit;International Journal of Colorectal Disease;2020-11-09

3. Pathology in Colorectal Malignancy;New Treatment Modalities in Rectal Cancer;2020

4. Pathologist’s perspective on primary rectal cancer;Abdominal Radiology;2019-07-20

5. The Role of the Laparoscopy on Circumferential Resection Margin Positivity in Patients With Rectal Cancer;Surgical Laparoscopy, Endoscopy & Percutaneous Techniques;2015-04

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