Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption

Author:

Maria Suzy12ORCID,Yunihastuti Evy12,Saldi Siti Rizny F.3,Djoerban Zubairi2

Affiliation:

1. Division of Allergy and Clinical Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

2. HIV Integrated Service, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia

3. Center for Clinical Epidemiology and Evidence Based Medicine (CEEBM), Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Abstract

There is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was evaluated at 6 to 18 months after the reintroduction. There were 100 patients included in our study, and 55 of them achieved virological success. History of single interruption (adjusted odds ratio [aOR] 5.51%, 95% confidence interval [CI] 1.82-16.68, P = .003) and CD4 count ≥200 cell/mm3 at the time of reintroduction (aOR 4.33, 95% CI 1.14-16.39, P = .031) increased likelihood to achieve virological success.

Publisher

SAGE Publications

Subject

Infectious Diseases,Dermatology,Immunology

Reference23 articles.

1. Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions

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4. Solem CT, Snedecor SJ, Khachatryan A. Burden of illness in a US commercially-insured HIV population: treatment patterns and costs. Paper presented at: 53rd ICAAC; September 10-13, 2013; Denver, CO.

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