HIV Drug Resistance Mutations in Patients with HIV and HIV-TB Coinfection After Failure of First-Line Therapy: A Prevalence Study in a Resource-Limited Setting

Author:

Khan Nawaid Hussain1,Kohli Mikashmi1,Gupta Kartik1,Das Bimal Kumar2,Pandey Ravindra Mohan3,Sinha Sanjeev1ORCID

Affiliation:

1. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India

2. Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India

3. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

Abstract

Introduction: The present study aimed to report the prevalent HIV-1 drug-resistant mutations in patients with HIV-1 alone and tuberculosis (TB) coinfection alone to improve our understanding of the mutation patterns and aid treatment decisions. Methods: Patients with HIV-1 and HIV-TB on treatment for more than 1 year with suspected failure were recruited. Sequencing of protease and two-thirds of the region of reverse transcriptase gene was done for drug-resistant mutations. Results: In the HIV-TB group (n = 25), 88%, 92%, and 12% had mutations to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs), respectively. In the HIV-alone group (n = 25), 84%, 100%, and 4% had mutations to NRTIs, NNRTIs, and PIs, respectively. M184V, M41L, D67N, G190A, A98G, and K103N were the most common mutations seen. Conclusion: There is a high prevalence of drug-resistant mutations in HIV and HIV-TB coinfected patients.

Publisher

SAGE Publications

Subject

Infectious Diseases,Dermatology,Immunology

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