Provider Perspectives on Rapid Treatment Initiation Among People Newly Diagnosed With HIV: A New Message of “Urgency”?

Author:

Uhrig Castonguay Breana J.1ORCID,Mancuso Noah234ORCID,Hatcher Sarah5ORCID,Watson Sable6,Okumu Eunice6,Abbott Rica5,Golin Carol E.167,Mobley Victoria8,Samoff Erika8,Swygard Heidi1,McNeil Candice J.5,Gay Cynthia L.1

Affiliation:

1. Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

2. Research Triangle Institute (RTI) International, Research Triangle Park, NC, USA

3. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA

4. Queer Health Collaborative (QHC), Atlanta, GA, USA

5. Department of Medicine, Section on Infectious Diseases, Wake Forest University School of Medicine, Wake Forest, NC, USA

6. Center for AIDS Research (CFAR), University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

7. Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

8. Division of Public Health, Communicable Disease Branch, North Carolina Department of Health and Human Services, Chapel Hill, NC, USA

Abstract

Background Early initiation of antiretroviral therapy improves human immunodeficiency virus (HIV) outcomes. However, achieving earlier treatment initiation is challenging for many reasons including provider awareness and clinic barriers; this study sought to understand perceptions of an early initiation program. Methods We interviewed 10 providers from 3 HIV clinics in North Carolina (October-November 2020). We asked providers about overall perceptions of early initiation and the pilot program. We developed narrative summaries to understand individual contexts and conducted thematic analysis using NVivo. Results Providers believed earlier initiation would signal an “extra sense of urgency” about the importance of antiretroviral therapy—a message not currently reflected in standard of care. Safety was a consistent concern. Cited implementation barriers included transportation assistance, medication sustainability, and guidance to address increased staff time and appointment availability. Conclusion Our qualitative findings highlight the need for training on the safety of early initiation and addressing staffing needs to accommodate quicker appointments.

Funder

Gilead Sciences

Publisher

SAGE Publications

Reference45 articles.

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3. World Health Organization. 2017 [cited 2023 Sep 20]. Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy [Internet]. Available from: https://www.who.int/publications-detail-redirect/9789241550062.

4. A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa

5. Early Antiretroviral Therapy Reduces AIDS Progression/Death in Individuals with Acute Opportunistic Infections: A Multicenter Randomized Strategy Trial

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