Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer-Reference-Cited by-同舟云学术

Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer

Published:2022-07 Issue:3 Volume:20 Page:155932582211155
ISSN:1559-3258
Container-title:Dose-Response
language:en
Short-container-title:Dose-Response

Author:

Jotic Ana¹²^ORCID,Milovanovic Jovica¹²,Savic-Vujovic Katarina³^ORCID,Radin Zorana⁴,Medic Branislava³^ORCID,Folic Miljan¹²,Pavlovic Bojan¹²^ORCID,Vujovic Aleksandar⁵,Dundjerovic Dusko⁶

Affiliation:

1. Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Center of Serbia, Belgrade, Serbia

2. Medical Faculty, University of Belgrade, Belgrade, Serbia

3. Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

4. Ear, Nose and Throat Clinic, Clinical Hospital Center Zvezdara, Belgrade, Serbia

5. ENT Hospital, Clinical Hospital Center ‘‘Dr Dragisa Misovic-Dedinje’‘ Belgrade, Serbia

6. Institute of Pathology, Medical Faculty, University of Belgrade, Belgrade, Serbia

Abstract

Objective The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. Material and Methods A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referral center. Tumor tissue was immunohistochemically stained for T-cell markers (CD4 and CD8), and levels of cytokines (IL-6 and IL-8) and C-reactive protein were analyzed from blood samples. Results Overall 3-year survival (OS) of patients included in the study was 69.2% and the disease specific survival (DSS) 72.5%. Higher expression of CD4+ and CD8+ were significant prognostic factors with positive impact on both OS and DSS in univariate analysis, but not in multivariate analysis. Levels of IL-8 were a significant predictor of 3-year OS and DSS survival in patients with advanced laryngeal cancer but not levels of IL-6 and CRP values. Conclusion Though high expression of CD4 and CD8 were demonstrated in the tumor tissue, but their prognostic role was not established. Higher values of IL-8 proved to be significant negative predictor of DSS. This could further collaborate the inclusion of combination of biomarkers in assessment of favorable treatment choice in patients with advanced laryngeal carcinoma.

Publisher

SAGE Publications

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/15593258221115537

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