Expression of Caveolin-1 Is Associated With Thyroid Function in Patients With Human Papillary Thyroid Carcinoma-Reference-Cited by-同舟云学术

Expression of Caveolin-1 Is Associated With Thyroid Function in Patients With Human Papillary Thyroid Carcinoma

Published:2020-04-01 Issue:2 Volume:18 Page:155932582091933
ISSN:1559-3258
Container-title:Dose-Response
language:en
Short-container-title:Dose-Response

Author:

Zhang Jingyi¹²³^ORCID,Yan Dongxia⁴,He Lianping⁵^ORCID,Zhang Qing⁴,Wen Shuang²,Liu Peiyu⁶,Zhou Hong²,Peng Yongde¹

Affiliation:

1. Department of Endocrinology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China

2. Department of Immunology, Nanjing Medical University, Nanjing, China

3. The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, China

4. Department of Pathology, Ma’anshan People’s Hospital, Ma’anshan, China

5. College of Experience Industry, Anhui Polytechnic University, Wuhu, Anhui, China

6. Department of Pharmacology, School of Basic Medical Science, Nanjing Medical University, Nanjing, China

Abstract

Objective: The aim of this study was to evaluate the levels of caveolin-1 in thyroid follicular epithelial cells of papillary thyroid cancer, follicular thyroid cancer, and nonmalignant thyroid nodule benign follicular adenoma, as well as to explore the relationship between the levels of caveolin-1 and thyroid function. Methods: Thirty cases of papillary thyroid cancer, 10 cases of follicular thyroid cancer, 32 cases of nonmalignant thyroid nodule benign follicular adenoma, and 30 controls were enrolled in this study. Caveolin-1 expression in tissue specimens obtained from these cases was evaluated by immunohistochemistry and Western blotting. Results: Caveolin-1 expression in thyroid epithelial cells of patients with papillary thyroid cancer, particularly female patients, was significantly higher than that in patients with follicular thyroid cancer and nonmalignant thyroid nodule benign follicular adenoma ( P < .005). Serum thyroid-stimulating hormone (TSH) levels in the caveolin-1-positive expression group were lower than that in the caveolin-1-negative expression group, and the lowest expression of caveolin-1 was detected in tissues of patients with Graves’ disease. The serum TSH level was associated with caveolin-1 expression in thyroid epithelial cells. Conclusion: Caveolin-1 may participate in regulating thyroid function and is a potential biomarker of follicular thyroid cancer.

Publisher

SAGE Publications

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1559325820919330

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