Impact of Valves in a Biomechanical Heart Model Assisting Failing Hearts

Author:

Guldner Norbert W1,Klapproth Peter1,Margaritoff Petra RJ1,Noel Ralf1,Sievers Hans H1,Grossherr Martin1

Affiliation:

1. Clinic of Cardiac Surgery University of Schleswig-Holstein Luebeck, Germany

Abstract

Experimental valveless muscular blood pumps (biomechanical hearts) in goats can pump more than 1 L·min−1, but due to a high pendulum volume, no significant flow contribution to the circulation is gained. Thus valved and valveless biomechanical hearts were compared for efficacy. Heart failure was induced in 5 adult Bore goats by repeated intracoronary embolization. A valved and balloon-equipped pumping chamber was integrated into the descending aorta, simulating standard biomechanical circulatory support. The valveless biomechanical heart supported a failing heart with a baseline cardiac output of 2,670 ± 710 mL·min−1 by contributing additional flow of 113 ± 37 mL·min−1. The biomechanical heart model incorporating an outlet valve offered an additional 304 ± 126 mL·min−1, and the use of 2 valves significantly enhanced pulmonary blood flow by 1,235 ± 526 mL·min−1. The use of 2 valves in biomechanical hearts seems to be essential to achieve adequate circulatory support. Double-valved biomechanical hearts driven by an appropriate skeletal muscle ventricle may contribute to the therapy of heart failure.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,General Medicine,Surgery

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3