Is serotonin a valuable parameter in peripheral arterial disease?

Abstract

Objective In this study, we aimed to evaluate the relationship of serum serotonin levels, which are supposed to affect vascular function, to peripheral arterial disease. Methods This prospective study was performed in 70 patients (57 males, 13 females; mean age 67 ± 13 years) with peripheral arterial disease scheduled for surgery and 70 controls (52 males, 18 females; mean age 58 ± 12 years). Results The rates of diabetes mellitus and hypertension and the fasting glucose levels were significantly higher in the peripheral arterial disease group ( p = 0.001). Total, low-density, and high-density cholesterol, triglycerides, urea, and creatinine levels, and the smoking rate were similar in both groups ( p > 0.05). The serotonin levels were significantly higher in patients with peripheral vascular disease scheduled for surgery compared to the control group ( p = 0.024). Conclusion The plasma serotonin level is an important parameter in peripheral arterial disease.