High immunoglobulin E level is associated with increased readmission in children with bronchopneumonia

Author:

You Cun1,Ran Guo2,Wu Xiao3,Wang Yu4,Tian Hua4,Fan Jiabao5,Yao Zezhong6,Wang Fei7ORCID

Affiliation:

1. Department of Pediatrics, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, China

2. Department of Anesthesiology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China

3. Emergency Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China

4. Jiuting Town Community Healthcare Center of Songjiang District, Shanghai, China

5. Department of Clinical Laboratory, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, China

6. Department of pediatrics, Minhang Branch, Zhongshan Hospital, Fudan University, No.170, Xinsong Rd, Minhang, Shanghai 201199, China

7. Emergency Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, No.1, Chengbei Rd, Jiading, Shanghai 201800, China

Abstract

Background: Increased immunoglobulin E (IgE) is associated with lower respiratory tract infections. The study aimed to evaluate the association between IgE and the rate of bronchopneumonia-related readmission within 12 months in children. Methods: A total of 1099 children aged over 1 year with bronchopneumonia, from 1 January 2015 to 31 December 2016, were enrolled. Unplanned readmissions within 12 months after discharge were observed. Multivariate regression analysis was used to identify independent risk factors for rehospitalization. Results: The rate of rehospitalization was 11.4% (125/1099). Compared to the nonreadmission children, IgE levels, the proportion of children with asthma and hospitalization duration were significantly higher in the readmission children ( p < 0.05). Compared to the children with normal IgE (≤ 165 IU/ml) levels, the risk of rehospitalization was significantly higher in children with abnormal IgE [odds ratio (OR) 1.781, 95% confidence interval (CI) 1.209–2.624, p = 0.004]. Children with IgE level more than three times the upper limit had even higher risks of readmission (OR 2.037, 95%CI 1.172–3.540, p = 0.012). Meanwhile, the risk of readmission in children with abnormal IgE combined with or without bronchial asthma was significantly higher (OR 2.548 and 1.918, 95% CI 1.490–4.358 and 1.218–3.020, p = 0.001 and 0.005, respectively). Conclusions: Children aged over 1 year with bronchopneumonia who had higher IgE levels are at increased risk for rehospitalization within the first 12 months of the index hospitalization and IgE level may be used as a predictor of rehospitalization in children with bronchopneumonia.

Funder

New Key Subjects of Jiading District, Shanghai Municipality

Science and Technology Commission of Minhang District, Shanghai Municipality

Publisher

SAGE Publications

Subject

Pharmacology (medical),Pulmonary and Respiratory Medicine

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