Prescriptions of opioid-containing drugs in patients with chronic cough-Reference-Cited by-同舟云学术

Prescriptions of opioid-containing drugs in patients with chronic cough

Published:2024-01 Issue: Volume:18 Page:
ISSN:1753-4666
Container-title:Therapeutic Advances in Respiratory Disease
language:en
Short-container-title:Ther Adv Respir Dis

Author:

Weiner Michael¹²³^ORCID,Liu Ziyue²,Schelfhout Jonathan⁴,Dexter Paul²⁵⁶,Roberts Anna R.⁷,Griffith Ashley⁵,Bali Vishal⁴,Weaver Jessica⁴

Affiliation:

1. Indiana University Center for Health Services and Outcomes Research, Regenstrief Institute, Inc., 1101 West 10th Street, Indianapolis, IN 46202-4800, USA

2. School of Medicine, Indiana University, Indianapolis, IN, USA

3. Center for Health Information and Communication, U.S. Department of Veterans Affairs, Veterans Health Administration, Health Systems Research CIN 13-416, Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA

4. Center for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA

5. Center for Biomedical Informatics, Regenstrief Institute, Inc., Indianapolis, IN, USA

6. Eskenazi Health, Indianapolis, IN, USA

7. Regenstrief Data Services, Regenstrief Institute, Inc., Indianapolis, IN, USA

Abstract

Background: Chronic cough (CC) affects about 10% of adults, but opioid use in CC is not well understood. Objectives: To determine the use of opioid-containing cough suppressant (OCCS) prescriptions in patients with CC using electronic health records. Design: Retrospective cohort study. Methods: Through retrospective analysis of Midwestern U.S. electronic health records, diagnoses, prescriptions, and natural language processing identified CC – at least three medical encounters with cough, with 56–120 days between first and last encounter – and a ‘non-chronic cohort’. Student’s t-test, Pearson’s chi-square, and zero-inflated Poisson models were used. Results: About 20% of 23,210 patients with CC were prescribed OCCS; odds of an OCCS prescription were twice as great in CC. In CC, OCCS drugs were ordered in 38% with Medicaid insurance and 15% with commercial insurance. Conclusion: Findings identify an important role for opioids in CC, and opportunity to learn more about the drugs’ effectiveness.

Funder

Merck Sharp & Dohme Corp., Inc.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/17534666241259373

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