Pathology Methods for the Evaluation of Embryonic and Perinatal Developmental Defects and Lethality in Genetically Engineered Mice-Reference-Cited by-同舟云学术

Pathology Methods for the Evaluation of Embryonic and Perinatal Developmental Defects and Lethality in Genetically Engineered Mice

Published:2011-12-06 Issue:1 Volume:49 Page:71-84
ISSN:0300-9858
Container-title:Veterinary Pathology
language:en
Short-container-title:Vet Pathol

Author:

Ward J. M.¹,Elmore S. A.²,Foley J. F.²

Affiliation:

1. Global VetPathology, Montgomery Village, Maryland

2. Cellular & Molecular Pathology Branch, National Toxicology Program, NIEHS, NIH, Research Triangle Park, North Carolina

Abstract

The normal embryonic development of organs and other tissues in mice and all species is preprogrammed by genes. Inactivation of a gene involved in any stage of normal embryonic development can have severe consequences leading to embryonic or postnatal developmental defects and lethality. Pathology methods are reviewed for evaluating normal and abnormal placenta and embryo, especially after E12.5. These methods include pathology protocols for necropsy and histopathology in addition to references that will provide additional knowledge for embryo assessment including histology atlases and advanced embryo imaging techniques.

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/0300985811429811

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