Affiliation:
1. Abteilung für Pathologie (amt. wiss. Abteilungsleiter Dr. med. vet. Chr. Tamaschke) des Instituts für Vergleichende Pathologie der Deutschen Akademie der Wissenschaften zu Berlin
Abstract
It was possible with the aid of suitable histochemical methods to demonstrate carboxyl and sulfate groups in amyloid deposits of animal tissues and ascribe them to various acid glycosaminoglycans and neuraminic acid. The principal glycosaminoglycan components in amyloid were hyaluronidase-resistant sulfated glycosaminoglycans. Their quantity varied within the various amyloid deposits and was apparently dependent on the age of amyloid depositions. Since special staining methods for demonstration of amyloid depend on the presence of acid radicals, the findings of this investigation explain the difficulties occasionally encountered with the histochemical demonstration of amyloid.