Affiliation:
1. Mason Research Institute, Worcester, Mass.; and The New England Regional Primate Center, Southborough, Mass.
Abstract
Numerous, lobulated, thin-walled protozoan cysts were found in the brain and cervical spinal cord of a male Fischer rat with granulomatous encephalitis. The cysts were compartmented, 470–1000 μm in diameter, and packed with crescent-shaped organisms. Light- and electron-microscopic features of the organism were characteristic of the protozoan Frenkelia, a parasite usually found in the brain of wild rodents. Many cysts were replaced by granulomas, whereas others elicited no inflammation. Perivascular and meningeal mononuclear cell infiltrates and gliosis were common.
Cited by
13 articles.
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