Mononuclear Cell Leukemia in Aged Sprague-Dawley Rats

Author:

Abbott D. P.1,Prentice D. E.1,Cherry C. P.1

Affiliation:

1. Department of Pathology, Huntingdon Research Centre, Huntingdon, Cambridgeshire, England

Abstract

A mononuclear cell leukemia in Sprague-Dawley rats is described in which liver, spleen, and lung involvement was a constant feature. The cell was 16 to 25 μm in diameter with round, oval or indented nucleus, and the cytoplasm contained bright red granules. This is the first report of such a leukemia in Sprague-Dawley rats and a comparison with mononuclear cell leukemia in other strains of laboratory rats is made.

Publisher

SAGE Publications

Subject

General Veterinary

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Malignant Lymphoma with Severe Infiltrative Growth into Skeletal Muscles in WBN/Kob Rats;Journal of Toxicologic Pathology;2009

2. Cytologic Diagnosis of Diseases of Rabbits, Guinea Pigs, and Rodents;Veterinary Clinics of North America: Exotic Animal Practice;2007-01

3. Lymphoid Neoplasms;Jubb, Kennedy & Palmer's Pathology of Domestic Animals;2007

4. Neoplastic Disease;The Laboratory Rat;2006

5. Unexpected tumour findings in lifetime rodent bioassay studies—what to do?;Toxicology Letters;2002-03

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